What is Pediatric Pharmacokinetics Base Equation?
Mathematical Foundation
Laws & Principles
- Metric Weight Conversion: Pediatric dosing guidelines are standardized in milligrams per kilogram (mg/kg). If weight is measured in pounds, it must first be converted to kilograms (divide pounds by 2.2046) before applying the dosage formula.
- Adult Maximum Ceiling: When calculating weight-based pediatric dosages for older or heavier children, the calculated dose must never exceed the recommended maximum single adult dose for that medication.
Step-by-Step Example Walkthrough
" A parent needs to give Acetaminophen to a 35-pound child. The bottle concentration is 160 mg per 5 mL, and the healthcare provider recommends 15 mg/kg per dose. "
- Convert to Metric: 35 lbs ÷ 2.2046 ≈ 15.88 kg.
- Calculate Target mg: 15.88 kg × 15 mg/kg ≈ 238.2 mg.
- Find Bottle Concentration: 160 mg ÷ 5 mL = 32 mg/mL.
- Calculate Liquid Volume: 238.2 mg ÷ 32 mg/mL ≈ 7.44 mL.